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  Contact Information:

  3001 Mercer University Dr

  122 Duvall Bldg

  Atlanta, GA 30341

  (678)-547-6246

  moniri_nh@mercer.edu

 

Education and Training

Post-Doctoral Fellow, Pharmacology

Duke University Medical Center, Durham, NC

 

Ph.D., Pharmaceutical Sciences

University of North Carolina, Chapel Hill, NC

 

B.S., Biological Sciences / Chemistry

Georgia State University, Atlanta, GA

 

 

Click here for Dr. Moniri's Complete CV or Biosketch

Bio

Dr. Moniri received a B.S. in Biological Sciences from Georgia State University and a Ph.D. in Pharmaceutical Sciences from the Division of Medicinal Chemistry at the School of Pharmacy at UNC - Chapel Hill.  Trained primarily in molecular pharmacology and medicinal chemistry, Dr. Moniri completed a post-doctoral fellowship at Duke University Medical Center and joined the faculty at the College of Pharmacy at Mercer in 2006.


 

 

Laboratory Research Focus Areas:

Dr. Moniri's training has focused on molecular pharmacology and signal transduction of G protein-coupled receptors (GPCR)  as well as the design and development of novel agents which modulate GPCR function.

Current research interests include characterization of free-fatty acid GPCRs, and their role in human health and disease, as well as the prototypical GPCR, the β2-adrenergic receptor, and the role that oxidative stress plays on β2AR function.

An NIH/NIDDK-funded study is focused on mechanisms of regulation of the recently discovered unsaturated free-fatty acid receptor FFA4, also known as GPR120.  Specifically, we are interested in the role that phosphorylation of FFA4 plays on its anti-inflammatory, and anti-diabetic effects.

A second project, recently funded by NIH/NINDS seeks to study the role of FFA receptors in the brain, particularly in regard to the role the receptor may play in Parkinson's Disease and related movement disorders.

Additionally, a recently funded NIH/NHLBI project investigates signaling of the prototypical GPCR, the β2-adrenergic receptor, to formation of intracellular reactive oxygen species (ROS). This project seeks to characterize the role of the β2-AR/ROS linkage in human airway diseases such as asthma. 

For more detailed information on research in the Moniri lab, click here.


 

Teaching:

Dr. Moniri currently teaches physiology, pathophysiology, pharmacology, and medicinal chemistry within various systems and disorders in the Doctor of Pharmacy (Pharm.D.) curriculum at the College of Pharmacy.

PharmD courses taught in include Musculoskeletal Disorders and Pain (P3), Endocrine Disorders (P3), Nervous System Disorders I and II (P2), and Infectious Diseases I & II (P3).

For more detailed information on teaching, click here.


 
 

Peer-Reviewed Publications:

 
 

(Click here for PubMed listing of publications)

 
 

Senatorov IS, Cheshmehkani A, Burns RN, Singh, K, Moniri NH.  Carboxy-terminal phosphoregulation of the long splice isoform of Free-Fatty Acid Receptor-4 mediates β-arrestin recruitment and signaling to ERK1/2.   Molecular Pharmacology.  97:304-313, 2020. 

Rambacher KM and Moniri NH. Cysteine redox state regulates human β2-adrenergic receptor binding and function. Scientific Reports. 10:2934, 1-15, 2020. 

Chitre NM, Wood BJ, Ray A, Moniri NH*, Murnane KS*.  Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum.  Neuropharmacology.  167:107976, 2020.
* denotes co-senior authors.

Rambacher KM and Moniri NH.  The β2-adrenergic receptor-ROS signaling axis:  An overlooked component of β2AR function?  Biochemical Pharmacology. 171: 113690, 2020.

Chitre N, Moniri NH, Murnane KS.  Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders.  CNS & Neurological Disorders - Drug Targets.  18(10):735-749, 2019.

Moniri NH. Reintroduction of quazepam: an update on comparative hypnotic and adverse effects. International Clinical Psychopharmacology. 34(6):275-285, 2019.

Murnane KS, Guner OF, Bowen JP, Rambacher KM, Moniri NH, Murphy TJ, Daphney CM, Oppong-Damoah A, Rice KC. The adrenergic receptor antagonist carvedilol interacts with serotonin 2A receptors both in vitro and in vivo. Pharmacology Biochemistry and Behavior. 181:37-45, 2019.

Moniri NH, Momary KM, McMahon TJ, Nayee E. Statin-associated Achilles tendon rupture and reproducible bilateral tendinopathy upon repeated exposure. Mayo Clinic Proceedings. 93(10):1531-1532, 2018.

Senatorov IS and Moniri NH. The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines. Biochemical Pharmacology.  150:170-180, 2018.

Cheshmehkani A, Senatorov IS, Dhuguru J, Ghoneim O, Moniri NH.  Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal β-arrestin phosphosensor in Raw264.7 macrophages.Biochemical Pharmacology. 146:139-150, 2017.

Moniri NH. Free-fatty acid receptor-4 (GPR120): cellular and molecular function and its role in metabolic disorders.  Biochemical Pharmacology. 110-111:1-15, 2016.

Cheshmehkani A, Senatorov IS, Kandi P, Singh M, Britt A, Hayslett R, Moniri NH.  Fish and flax seed oil supplemented diets increase FFAR4 expression in the rat colon.  Inflammation Research. 64(10):809-15, 2015.

Singh M and Moniri NH.  Reactive oxygen species as β-adrenergic receptor signal transducers.  Journal of Pharmaceutics and Pharmacology.  2(1): 8-15, 2014.  

Burns RN, Singh M, Senatorov IS, Moniri NH.    Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr347, Ser350, and Ser357 in the C-terminal tail.  Biochemical Pharmacology. 87:650-659, 2014.

Ryan GJ, Moniri NH, Smiley DD.  Clinical effects of once-weekly exenatide for the treatment of type 2 diabetes mellitus.  American Journal of Health-System Pharmacy. 70(13):1123-1131, 2013.

Gleason BL, Siracuse MV, Moniri NH, Birnie CR, Okamoto CT, Crouch MA.  Evolution of Preprofessional Pharmacy Curricula.  American Journal of Pharmaceutical Education. 77(5):95; 1-8, 2013.
 
Singh M and Moniri NH.  Reactive oxygen species are required for β2-adrenergic receptor-β-arrestin interactions and signaling to ERK1/2. Biochemical Pharmacology. 84:661-669, 2012.  
 
Burns RN and Moniri NH.  Agonist- and Hydrogen peroxide- mediated oxidation of the β2 adrenergic receptor: evidence of receptor S-sulfenation as detected by a modified biotin switch assay.  Journal of Pharmacology and Experimental Therapeutics.  339(3):914-921, 2011.
 
Wang Z, Humphrey C, Frilot N, Wang G, Nie Z, Moniri NH, Daaka Y.  Dynamin2- and endothelial nitric oxide synthase-regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli.  Journal of Cell Biology. 10;192(1):101-10, 2011.
 
Burns RN and Moniri NH.  Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor.  Biochemical and Biophysical Research Communications. 396: 1030-1035, 2010.
 
Bagchi G, Wu J, French J, Kim J, Moniri NH, Daaka Y.  Androgens transduce the Gαs-mediated activation of protein kinase A in prostate cells.  Cancer Research. 68: 3225-3231, 2008.
 
Moniri NH and Daaka Y.  Agonist-stimulated reactive oxygen species formation regulates β2-adrenergic receptor signal transduction.  Biochemical Pharmacology. 74: 64-73, 2007.
 
Booth RG and Moniri NH.  Novel ligands stabilize stereo-selective conformations of the histamine H1 receptor to activate catecholamine synthesis. Inflammation Research. 56:S1-2, 2007.
 
Moniri NH and Booth RG.  Role of PKA and PKC in Histamine H1 Receptor-Mediated Activation of Catecholamine Neurotransmitter Synthesis.  Neuroscience Letters. 407:249-253, 2006.
 
Bagchi G, Moniri NH, Daaka Y.  Androgen Receptor.   AfCS-UCSD-Nature Molecule Pages. 2006.  (doi:10.1038/mp.a003790.01)
 
Guo R, Kasbohm EA, Arora P, Sample CJ, Baban B, Sud N, Sivashanmugam P, Moniri NH, Daaka Y.  Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells.  Endocrinology. 147:4883-4892, 2006.
 
Wang G, Moniri NH, Ozawa K, Stamler JS, Daaka Y.  Nitric oxide regulates endocytosis by S-nitrosylation of dynamin.  Proceedings of the National Academy of Sciences, USA. 103(5):1295-1300, 2006.
 
Booth RG and Moniri NH.  Ligand-directed multifunctional signaling of histamine H1 receptors.  Inflammation Research. 54:S44-45, 2005.
 
Moniri NH, Covington-Strachan DW, Booth RG.  Ligand-directed functional heterogeneity of histamine H1 receptors:  Novel agonists selectively activate and block H1 mediated phospholipase C and adenylyl cyclase signaling in CHO cells.  Journal of Pharmacology and Experimental Therapeutics. 311:274-281, 2004.
 
Moniri NH and Booth RG.  Functional heterogeneity of histamine H1 receptors.  Inflammation Research. 53:S71-72, 2004.
 
Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H, Leurs R.  A novel phenylaminotetralin radioligand reveals a sub-population of histamine H1 receptors.  Journal of Pharmacology and Experimental Therapeutics. 302:328-336, 2002.


 
 

Book Chapters:

 
 

Moniri NH.  Drugs used to induce/support sedation or anesthesia.  Foye’s Principles of Medicinal Chemistry.  Chapter 12.  Roche VF and Zito SW, Lemke TL, Williams DA, eds.  Lippincott, Williams, & Wilkins, Philadelphia, PA, 8th ed., 2019.

Moniri NH.   Sedative-Hypnotics.  Foye’s Principles of Medicinal Chemistry.  Lemke TL and Williams DA, eds.  Lippincott, Williams, & Wilkins, Baltimore, MD, 7th ed., 2012.


 
 

Published Proceedings:

 

Rambacher KM and Moniri NH.  Redox deficient cysteine residues impair β2-adrenergic receptor function.  The FASEB Journal, 33(1S):668.3.  Presented at Experimental Biology (ASPET), Orlando, FL, 2019.

Chitre NM, Wood B, Ray A, Moniri NH, Murnane KS.  Assessing the neuroprotective effects of docosahexaenoic acid in 6-hydroxydopamine induced Parkinsonism in rats.  The FASEB Journal, 33(1S):501.10.  Presented at Experimental Biology (ASPET), Orlando, FL, 2019.

Moniri NH and Sambunaris A. The Institute for Advanced Medical Research at Mercer University: Translational and Clinical Research Opportunities for Students. American Journal of Pharmaceutical Education. 82(5): 25. Presented at American Association of Colleges of Pharmacy, Boston, MA, 2018.

Rambacher KM and Moniri NH.  Ligand Binding to the β2-Adrenergic Receptor Is Dependent Upon Its Oxidation State.  The FASEB Journal, 32(1S):555.14.  Presented at Experimental Biology (ASPET), San Diego, CA, 2018.

Senatorov IS, Cheshmehkani A, Moniri NH.  Investigating Phosphorylation Differences in FFA4 Short and Long Isoforms.  The FASEB Journal, 32(1S):555.30.  Presented at Experimental Biology (ASPET), San Diego, CA, 2018.

Cheshmehkani A and Moniri NH.  Effects of phosphodefective FFA4 receptor C-terminal mutants on COX-2 expression in macrophages.  The FASEB Journal, 31(1S):992.10.  Presented at Experimental Biology (ASPET), Chicago, IL, 2017.

Spry R, Hibicke M, Rogers D, Rambacher KM, Hayslett R, Moniri N, Murnane K.  A new testing paradigm for evaluating motor and non-motor symptoms of 6-hydroxydopamine lesions in rats.  The FASEB Journal, 31(1S):662.7.  Presented at Experimental Biology (ASPET), Chicago, IL, 2017.

Murnane KS, Guner O, Moniri NH, Bowen P. Ligand-based pharmacophore modeling of 5-HT2A receptor biased agonism. The FASEB Journal, 29:768.12.  Presented at Experimental Biology (ASPET), Boston, MA, 2015.

Singh M and Moniri NH.  Role of reactive oxygen species as signal transducers in β2-adrenergic receptor mediated β-arrestin signaling.   The FASEB Journal, 28:662.2. Presented at Experimental Biology (ASPET), San Diego, CA, 2014.

Singh M and Moniri NH.  Brighter side of reactive oxygen species (ROS) revealed in β2 adrenergic receptor-β-arrestin interactions and signaling to ERK1/2.  Molecular Biology of the Cell. Presented at the annual meeting of the American Society for Cell Biology, Abstract #592, New Orleans, LA, 2013.

Singh M and Moniri NH.  Reactive Oxygen Species are required for β2-adrenergic receptor mediated β-arrestin signaling.  The FASEB Journal, 26:665.6.Presented at Experimental Biology (ASPET), San Diego, CA, 2012.

Burns RN and Moniri NH. Elucidation of the phosphorylation profiles of the long and short isoforms of the omega-3 fatty acid receptor-1 (GPR120). The FASEB Journal, 26:837.7. Presented at Experimental Biology (ASPET), San Diego, CA, 2012.

Burns RN and Moniri NH.  Agonist-dependent oxidation of the β2 adrenergic receptor:  Selective cysteine sulfenic acid formation detected by a modified biotin switch assay.  The FASEB Journal, 25:629.7.  Presented at Experimental Biology (ASPET),Washington, DC, 2011.

Burns RN and Moniri NH.  Omega-3 fatty acid mediated phosphorylation of the short and long human GPR120 receptor isoforms.  The FASEB Journal, 24:585.6. Presented atExperimental Biology (ASPET),Anaheim, CA, 2010.

Moniri NH and Daaka Y.  β2-adrenergic receptor mediated generation of reactive oxygen species is a component required for signal transduction, desensitization, and homodimerization.  The FASEB Journal, 22:723.6.  Presented at Experimental Biology (ASPET),San Diego, CA, 2008.


 

Proffesional Publications:

 
 

Metzger NL, O’Brien KA, Moniri NH, Peasah SK.  Sanford Guide Improves At-Risk Student Performance in an Infectious Disease Series.  Let’s think about it!   19(1):1-9, 2018. 

Moniri NH.   The Use of a Patient-based Medicinal Chemistry Case in the Nervous System I Course.  Let’s think about it!  11(2):1-3, Spring, 2008.


 
 

 

 
     
     
     
 
Last Updated: 5/11/2020
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