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  Contact Information:

  3001 Mercer University Dr

  122 Duvall Bldg

  Atlanta, GA 30341

  (678)-547-6246

  moniri_nh@mercer.edu

 

Education and Training

Post-Doctoral Fellow, Pharmacology

Duke University Medical Center, Durham, NC

 

Ph.D., Pharmaceutical Sciences

University of North Carolina, Chapel Hill, NC

 

B.S., Biological Sciences / Chemistry

Georgia State University, Atlanta, GA

 

 

Click here for Dr. Moniri's Complete CV or Biosketch

Bio

Dr. Moniri received a B.S. in Biological Sciences from Georgia State University and a Ph.D. in Pharmaceutical Sciences from the Division of Medicinal Chemistry at the School of Pharmacy at UNC - Chapel Hill.  Trained primarily in molecular pharmacology and medicinal chemistry, Dr. Moniri completed a post-doctoral fellowship at Duke University Medical Center and joined the faculty at the College of Pharmacy and Health Sciences at Mercer in 2006.

 

Laboratory Research Focus Areas:

Dr. Moniri's training has focused on molecular pharmacology and signal transduction of G protein-coupled receptors (GPCR)  as well as the design and development of novel agents which modulate GPCR function.

Current research interests include characterization of neuro-endocrine GPCRs which are involved in glucagon/insulin homeostasis, food intake, and satiety, as well as development of novel anti-diabetic agents which target these GPCRs. 

An NIH/NIDDK-funded study is focused on mechanisms of regulation of the recently discovered unsaturated free-fatty acid receptor FFA4, also known as GPR120.  Specifically, we are interested in the role that phosphorylation of FFA4 plays on its anti-inflammatory, and anti-diabetic effects.

A second project, recently funded by NIH/NINDS seeks to study the role of FFA4 in the brain, particularly in regard to the role the receptor may play in Parkinson's Disease and related movement disorders.

Additionally, the Moniri laboratory is interested in signaling of the prototypical GPCR, the β2-adrenergic receptor, to formation of intracellular reactive oxygen species (ROS).  We have shown that agonism of the β2AR leads to ROS generation, which itself regulates receptor function.  We are interested in further studying the role of this pathway in human airway diseases as well as in the cardiovascular system.

For more detailed information on research in the Moniri lab, click here.

 

Teaching:

Dr. Moniri currently teaches physiology, pathophysiology, pharmacology, and medicinal chemistry within various systems and disorders in the Doctor of Pharmacy (Pharm.D.) curriculum at the College of Pharmacy.

PharmD courses taught in include Musculoskeletal Disorders and Pain (P3), Endocrine Disorders (P3), Nervous System Disorders I and II (P2), and Infectious Diseases I & II (P3).

Ph.D. Courses taught in include Methods in Cell and Molecular Biology

For more detailed information on teaching, click here.

 
 

Peer-Reviewed Publications:

 
 

(Click here for PubMed listing of publications)

 
 

Moniri NH. Free-fatty acid receptor-4 (GPR120): cellular and molecular function and its role in metabolic disorders.  Biochemical Pharmacol, 110-111:1-15, 2016.

Cheshmehkani A, Senatorov IS, Kandi P, Singh M, Britt A, Hayslett R, Moniri NH.  Fish and flax seed oil supplemented diets increase FFAR4 expression in the rat colon.  Inflamm Res, 64(10):809-15, 2015.

Singh M and Moniri NH.  Reactive oxygen species as β-adrenergic receptor signal transducers.  J. Pharmaceu Pharmacol.  2(1): 8-15, 2014.  

Burns RN, Singh M, Senatorov IS, Moniri NH.    Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr347, Ser350, and Ser357 in the C-terminal tail.  Biochem Pharmacol, 87:650-659, 2014.

Ryan GJ, Moniri NH, Smiley DD.  Clinical effects of once-weekly exenatide for the treatment of type 2 diabetes mellitus.  Am J Health Syst Pharm, 70(13):1123-1131, 2013.

Gleason BL, Siracuse MV, Moniri NH, Birnie CR, Okamoto CT, Crouch MA.  Evolution of Preprofessional Pharmacy Curricula.  Am J Pharm Educ, 77(5):95; 1-8, 2013.
 
Singh M and Moniri NH.  Reactive oxygen species are required for β2-adrenergic receptor-β-arrestin interactions and signaling to ERK1/2.  Biochem Pharmacol, 84:661-669, 2012.  
 
Burns RN and Moniri NH.  Agonist- and Hydrogen peroxide- mediated oxidation of the β2 adrenergic receptor: evidence of receptor S-sulfenation as detected by a modified biotin switch assay.  J Pharmacol Exper Ther,  339(3):914-921, 2011.
 
Wang Z, Humphrey C, Frilot N, Wang G, Nie Z, Moniri NH, Daaka Y.  Dynamin2- and endothelial nitric oxide synthase-regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli.  J Cell Bio, 10;192(1):101-10, 2011.
 
Burns RN and Moniri NH.  Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor.  Biochem Biophys Res Commun, 396: 1030-1035, 2010.
 
Bagchi G, Wu J, French J, Kim J, Moniri NH, Daaka Y.  Androgens transduce the Gαs-mediated activation of protein kinase A in prostate cells.  Cancer Res, 68: 3225-3231, 2008.
 
Moniri NH and Daaka Y.  Agonist-stimulated reactive oxygen species formation regulates β2-adrenergic receptor signal transduction.  Biochem Pharmacol, 74: 64-73, 2007.
 
Booth RG and Moniri NH.  Novel ligands stabilize stereo-selective conformations of the histamine H1 receptor to activate catecholamine synthesis. Inflamm Res, 56:S1-2, 2007.
 
Moniri NH and Booth RG.  Role of PKA and PKC in Histamine H1 Receptor-Mediated Activation of Catecholamine Neurotransmitter Synthesis.  Neurosci Lett, 407:249-253, 2006.
 
Bagchi G, Moniri NH, Daaka Y.  Androgen Receptor.   AfCS-UCSD-Nature Molecule Pages, 2006.  (doi:10.1038/mp.a003790.01)
 
Guo R, Kasbohm EA, Arora P, Sample CJ, Baban B, Sud N, Sivashanmugam P, Moniri NH, Daaka Y.  Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells.  Endocrinology, 147:4883-4892, 2006.
 
Wang G, Moniri NH, Ozawa K, Stamler JS, Daaka Y.  Nitric oxide regulates endocytosis by S-nitrosylation of dynamin.  Proc Natl Acad Sci, USA, 103(5):1295-1300, 2006.
 
Booth RG and Moniri NH.  Ligand-directed multifunctional signaling of histamine H1 receptors.  Inflamm Res, 54:S44-45, 2005.
 
Moniri NH, Covington-Strachan DW, Booth RG.  Ligand-directed functional heterogeneity of histamine H1 receptors:  Novel agonists selectively activate and block H1 mediated phospholipase C and adenylyl cyclase signaling in CHO cells.  J Pharmacol Exper Ther, 311:274-281, 2004.
 
Moniri NH and Booth RG.  Functional heterogeneity of histamine H1 receptors.  Inflamm Res, 53:S71-72, 2004.
 
Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H, Leurs R.  A novel phenylaminotetralin radioligand reveals a sub-population of histamine H1 receptors.  J Pharmacol Exper Ther, 302:328-336, 2002.

 
 

Book Chapters:

 
 

Moniri NH.   Sedative-Hypnotics.  Foye’s Principles of Medicinal Chemistry.  Lemke TL and Williams DA, eds.  Lippincott, Williams, & Wilkins, Baltimore, MD, 7th ed., 2012.

 
 

Invited Lectures and Presentations:

 

Cheshmehkani and Moniri NH.  Effects of phosphodefective FFA4 receptor C-terminal mutants on COX-2 expression in macrophages.  The FASEB Journal, 31(1S):992.10.  Presented at Experimental Biology (ASPET), Chicago, IL, 2017.

Spry R, Hibicke M, Rogers D, Rambacher K, Hayslett R, Moniri N, Murnane K.  A new testing paradigm for evaluating motor and non-motor symptoms of 6-hydroxydopamine lesions in rats.  The FASEB Journal, 31(1S):662.7.  Presented at Experimental Biology (ASPET), Chicago, IL, 2017.

Rambacher KC and Moniri NH.  The impact of reactive oxygen species induced cysteine S-sulfenation on β2-adrenergic receptor function.  Presented at Mercer University Atlanta Research Conference, Atlanta, GA, 2017.

Cheshmehkani A and Moniri NH.  Effects of Phosphodefective FFAR4 C-terminal Mutants on COX-2 Expression in Macrophages.  Presented at Mercer University Atlanta Research Conference, Atlanta, GA, 2017.

Senatorov I and Moniri NH.  Phosphoregulation of the long splice isoform of Free Fatty Acid Receptor-4.  Presented at Mercer University Atlanta Research Conference, Atlanta, GA, 2017.

Moniri NH.  Regulation of free-fatty acid receptor-4:  implications for anti-inflammatory signaling.  Presented at Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 2017.

Irvin T, Morgan JB, Deck J, Murnane KS, Moniri NH, Bowen P, Guner O, Jacobson A, and Rice KC.  Synthesis and Characterization of 9-oxophenylmorphans: Potential Biased 5-HT2A Receptor Agonists.  Presented at Gordon Research Conference: Heterocylic Compounds, Newport, RI, 2016.

Irvin T, Morgan JB, Deck J, Murnane KS, Moniri NH, Bowen P, Guner O, Jacobson A, and Rice KC.   Synthesis and Characterization of 9-oxophenylmorphans: Potential Biased 5-HT2A Receptor Agonists. Presented at Behavior, Biology, and Chemistry:  Translational Research in Addiction, San Antonio, TX, 2016.

Moniri NH. The brighter side of ROS: Uncovering a role for ROS in b2-adrenergic receptor function. Presented at Mercer University School of Medicine/College of Pharmacy Joint Research Symposium, Macon, GA, 2015.

Murnane KS, Guner O, Moniri NH, Bowen P. Ligand-based pharmacophore modeling of 5-HT2A receptor biased agonism. The FASEB Journal, 29:768.12.  Presented at Experimental Biology (ASPET), Boston, MA, 2015.

Cheshmehkani A and Moniri NH.  Effects of reactive oxygen species on agonist and antagonist
binding to the β2-adrenergic receptor.  Presented at GRASP conference, Atlanta, GA 2014.

Burns RN, Singh M, Senatorov IS, Moniri NH.  Mechanisms of homologous and heterologous phosphorylation of the anti-inflammatory and anti-diabetic Free-Fatty Acid Receptor FFA4 (GPR120).  Presented at American Association of Colleges of Pharmacy, Grapevine, TX, 2014.

Singh M and Moniri NH.  Role of reactive oxygen species as signal transducers in b2-adrenergic receptor mediated b-arrestin signaling.   The FASEB Journal, 28:662.2. Presented at Experimental Biology (ASPET), San Diego, CA, 2014.

Singh M and Moniri NHBrighter side of reactive oxygen species (ROS) revealed in β2-adrenergic receptor-β-arrestin interactions and signaling to ERK1/2.  Presented at the annual meeting of the American Society for Cell Biology, Abstract #592, New Orleans, LA, 2013.

Moniri NH.  A brighter side of ROS: Uncovering a role for ROS in β2-adrenergic receptor function.  Presented at the Center for Drug Discovery, Northeastern University, Boston, MA, April 23, 2013. 

Moniri NH*, Gleason BL*, Birnie CR, Crouch MA, Okamoto CT, Siracuse MV, McKay AB.  The evolving landscape of pre-professional pharmacy curricula.  Presented at the annual meeting of the American Association of Colleges of Pharmacy, Orlando, FL, 2012.  * denotes presenters.
 
Singh M and Moniri NH.  Reactive Oxygen Species are required for β2-adrenergic receptor mediated β-arrestin signaling.  The FASEB Journal.  Presented at Experimental Biology (ASPET), Abstract #665.6, San Diego, CA, 2012.
 
Burns RN and Moniri NH.  Elucidation of the phosphorylation profiles of the long and short isoforms of the omega-3 fatty acid receptor-1 (GPR120).  The FASEB Journal.  Presented at Experimental Biology (ASPET), Abstract #837.7, San Diego, CA, 2012.
 
Moniri NH.  Alternative teaching strategies in the classroom:  Development of critical thinking skills using case studies.  Presented at Mercer University Georgia Baptist College of Nursing Faculty Retreat, January 5, 2012.
 
Moniri NH.  Development of critical thinking skills using case studies.  Presented for the Mercer University Council of Deans, September 9, 2011.
 
Moniri NH.  Oxidation of G protein-coupled receptors:  The role of ROS on β2 adrenergic receptor signaling.  Presented at Mercer University College of Pharmacy and Health Sciences Research Symposium, August 12, 2011.
 
Moniri NH, Strom, JG, Ashworth LE, Barnett CW, Bartling JW, Klein CM.  A continuous improvement process for integrated basic and clinical sciences courses in the PharmD curriculum.  Presented at the annual meeting of the American Association of Colleges of Pharmacy, San Antonio, TX, 2011.
 
Burns RN and Moniri NH.  Agonist-dependent oxidation of the β2 adrenergic receptor:  Selective cysteine sulfenic acid formation detected by a modified biotin switch assay.  The FASEB Journal.  Presented at Experimental Biology (ASPET), Abstract #629.7, Washington, DC, 2011.
 
Moniri NH.  Regulation of the insulinotropic omega-3 fatty acid receptor GPR120 by phosphorylation.  Presented at The Medical Center of Central Georgia – Joint Research Conference, December 9, 2010.
 
Burns RN and Moniri NH.  Omega-3 fatty acid mediated phosphorylation of the short and
long human GPR120 receptor isoforms.  The FASEB Journal.  Presented at Experimental Biology (ASPET), Abstract #585.6, Anaheim, CA, 2010.
 
Moniri NH.  Regulation of β2-adrenergic receptor signaling by reactive oxygen species.  Invited Seminar.  Presented at Georgia State University, Dept. of Biology, December 4, 2009.
 
Moniri NH and Daaka Y.  β2-adrenergic receptor mediated generation of reactive oxygen species is a component required for signal transduction, desensitization, and homodimerization.  The FASEB Journal.  Presented at Experimental Biology (ASPET), Abstract #723.6, San Diego, CA, 2008.
 
Neal RL, Hendy MA, Moniri NH.  Cloning, expression, and initial functional characterization of the human and rat free-fatty acid receptor GPR120.  American Society for Pharmacology and Experimental Therapeutics - SE Region Abstracts.  Presented at ASPET-SEPS Region meeting, Augusta, GA, 2007. 
 
Booth RG and Moniri NH.  Functionally selective ligands for the Histamine H1 GPCR.  Experimental Biology meeting abstracts. Presented at Experimental Biology (ASPET), San Diego, CA, 2005.
 
Moniri NH and Booth RG.  Functionally selective histamine H1 receptor ligands stimulate tyrosine hydroxylase in bovine adrenal chromaffin cells:  effects of PKC and PKA inhibition on H1-mediated catecholamine synthesis.  Society for Neuroscience Abstracts, Vol. 29, presented at Society for Neuroscience Meeting, New Orleans, LA, 2003.
 
Legere JA, Moniri NH, Booth RG.  (±)-2-Dimethylamino-5-phenyl-1,2,3,4- tetrahydronaphthalene binds to histamine H1 receptors and selectively modulates cAMP vs. IP signaling pathways.  American Chemical Society Abstracts, Paper #590220, presented at American Chemical Society Meeting, New Orleans, LA, 2003.
 
Legere JA, Moniri NH, Booth RG.  2-Dimethylamino-5-phenyl-1,2,3,4-tetrahydronaphthalenes: A new class of ligands for histamine H1 and serotonin 5-HT2 type receptors.  American Chemical Society Abstracts, Paper #43231, presented at American Chemical Society Meeting, New York City, NY, 2003.
 
Moniri NH, Wyrick SD, Booth RG.  Novel ligands selectively activate histamine H1 receptors coupled to IP vs. cAMP signaling pathways to stimulate tyrosine hydroxylase.  Society for Neuroscience Abstracts, Vol. 28, Program No. 830.13, presented at Society for Neuroscience Meeting, Orlando, FL, 2002.
 
Ghoneim OM, Covington DW, Moniri NH, Booth RG.  Novel phenylaminotetralins stimulate IP accumulation and dopamine synthesis in rat striatum.  Society for Neuroscience Abstracts, Vol. 28, Program No. 249.5, presented at Society for Neuroscience Meeting, Orlando, FL, 2002.

 Moniri NH, Wyrick, SD, Booth RG.  New rigid diarylaminopropanes are histamine H1 ligands that stimulate brain dopamine synthesis.  Society for Neuroscience Abstracts, Vol. 27, Program No. 479.20, presented at Society for Neuroscience Meeting, San Diego, CA, 2001.

     
     
     
 
Last Updated: 4/21/2017
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