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Contact Information:
3001
Mercer University Dr
122
Duvall Bldg
Atlanta, GA 30341
(678)-547-6246
moniri_nh@mercer.edu
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Education and Training
Post-Doctoral Fellow, Pharmacology
Duke
University Medical Center, Durham, NC
Ph.D.,
Pharmaceutical Sciences
University of North Carolina, Chapel Hill, NC
B.S.,
Biological Sciences / Chemistry
Georgia
State University, Atlanta, GA
Click here for
Dr. Moniri's
Complete CV or
Biosketch
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Bio
Dr. Moniri received a B.S. in Biological Sciences from Georgia State
University and a Ph.D. in Pharmaceutical Sciences from the Division
of Medicinal Chemistry at the School of Pharmacy at UNC - Chapel
Hill. Trained primarily in molecular pharmacology and
medicinal chemistry, Dr. Moniri completed a post-doctoral fellowship
at Duke University Medical Center and joined the faculty at the
College of Pharmacy and Health Sciences at Mercer in 2006.
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Research Background and Interests
Dr. Moniri's training has focused on molecular
pharmacology and signal transduction of G protein-coupled receptors
(GPCR) as well as the design and development of novel agents
which modulate GPCR function.
Current research interests include
signal transduction, alternative signaling, and design of
functionally selective modulators of the prototypical GPCR, the
β2-adrenergic receptor.
Specifically, this work seeks to characterize mechanisms of
β2-receptor
mediated generation of intracellular reactive oxygen species,
formation of which we have recently shown to be indispensable for
receptor function.
The Moniri lab is also interested
in characterization of neuro-endocrine GPCRs which are involved in
glucagon/insulin homeostasis, food intake, and satiety, as well as
development of novel anti-diabetic agents which target these GPCRs.
One such project focuses on mechanisms of regulation of the recently
discovered unsaturated free-fatty acid receptor FFA4, also known as
GPR120.
For more detailed information on
research in the Moniri lab click here.
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Teaching
Dr. Moniri currently teaches physiology, pharmacology, and medicinal
chemistry in various systems and disorders within the Doctor of
Pharmacy (Pharm.D.) curriculum at the College of Pharmacy and Health
Sciences.
PharmD courses taught in include Musculoskeletal
Disorders (P3), Endocrine Disorders (P3), Nervous System Disorders
(P2), and Infectious Disease (P3).
PhD courses taught in include Methods in Cell and
Molecular Biology.
For more detailed information on teaching
click
here. |
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Publications
(Click here for
PubMed listing of publications)
Ryan GJ, Moniri NH,
Smiley DD.
Clinical effects of once-weekly
exenatide for the treatment of type 2 diabetes mellitus.
Am
J Health Syst Pharm, 70(13):1123-1131, 2013.
Gleason BL, Siracuse MV,
Moniri NH, Birnie
CR, Okamoto CT, Crouch MA.
Evolution of Preprofessional Pharmacy
Curricula.
Am
J Pharm Educ, 77(5):95; 1-8, 2013.
Singh M and Moniri NH. Reactive oxygen species are
required for
β2 adrenergic receptor-β-arrestin
interactions and signaling to ERK1/2. Biochem Pharmacol.
84(5):661-669, 2012.
Burns RN and
Moniri NH.
Agonist- and H2O2-
mediated oxidation of the β2 adrenergic receptor:
evidence of receptor S-sulfenation as detected by a modified biotin
switch assay.
J Pharmacol
Exp Ther.
339(3):914-921,
2011.
Wang Z, Humphrey C, Frilot N, Wang G, Nie Z,
Moniri NH, Daaka Y.
Dynamin2- and endothelial
nitric oxide synthase-regulated invasion of bladder epithelial cells
by uropathogenic Escherichia coli.
J Cell Biol.
10;192(1):101-10, 2011.
Burns RN and
Moniri NH.
Agonism with the omega-3 fatty acids
alpha-linolenic acid and docosahexaenoic acid mediates
phosphorylation of both the short and long isoforms of the human
GPR120 receptor.
Biochem Biophys Res Commun.,
396:
1030-1035, 2010.
Bagchi G, Wu J, French J, Kim
J,
Moniri NH, Daaka
Y. Androgens transduce the G
as-mediated activation of protein kinase A in
prostate cells.
Cancer Res.,
68(9): 3225-31, 2008.
Moniri NH. The use of a patient-based
medicinal chemistry case in the Nervous System I course. Let’s
think about it! 11(2):1-3, Spring, 2008.
Moniri NH and Daaka Y. Agonist-stimulated reactive oxygen
species formation regulates
β2-adrenergic
receptor signal transduction.
Biochem Pharmacol., 74: 64-73, 2007.
Booth, RG and
Moniri, NH. Novel ligands stabilize stereo-selective
conformations of the histamine H1 receptor to activate catecholamine
synthesis. Inflamm Res., 56:S1-2, 2007.
Moniri, NH and Booth,
RG. Role of PKA and PKC in histamine H1 receptor-mediated
activation of catecholamine neurotransmitter synthesis.
Neurosci Lett., 407:249-253, 2006.
Bagchi, G;
Moniri, NH; Daaka Y. Androgen Receptor.
AfCS-Nature Molecules Pages, 2006.
Guo, R; Kasbohm,
EA; Arora, P; Sample, CJ; Baban, B; Sud, N; Sivashanmugam, P;
Moniri, NH; Daaka, Y. Expression and function of
lysophosphatidic acid LPA1 receptor in prostate cancer cells.
Endocrinology, 147:4883-4892, 2006.
Wang, G;
Moniri, NH; Ozawa, K; Stamler JS; Daaka, Y. Nitric oxide
regulates endocytosis by S-nitrosylation of dynamin.
Proc Natl Acad Sci., USA,
103(5):1295-1300, 2006.
Booth, RG and
Moniri, NH. Ligand-directed multifunctional signaling of
histamine H1 receptors. Inflamm Res,
54:S44-45, 2005.
Moniri, NH;
Covington-Strachan, DW; Booth, RG. Ligand-directed functional
heterogeneity of histamine H1 receptors: Novel
agonists selectively activate and block H1 mediated
phospholipase C and adenylyl cyclase signaling in CHO cells.
J Pharmacol Exp Ther., 311:274-281, 2004.
Moniri, NH
and Booth, RG. Functional heterogeneity of histamine H1
receptors. Inflamm Res, 53:S71-72, 2004.
Booth, RG;
Moniri, NH; Bakker, RA; Choksi, NY; Nix, WB; Timmerman, H;
Leurs, R. A novel phenylaminotetralin radioligand reveals a
sub-population of histamine H1 receptors. J Pharmacol Exp
Ther., 302:328-336, 2002.
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Book Chapters
Moniri NH.
Sedative-Hypnotics
(Chapter 15).
Foye’s Principles of Medicinal Chemistry.
Lemke TL and Williams DA, eds.
Lippincott, Williams, & Wilkins,
Baltimore, MD, 7th ed., 2012.
Invited Lectures, Presentations and Abstracts
Moniri NH*,
Gleason BL*, Birnie CR, Crouch MA, Okamoto CT, Siracuse MV, McKay AB.
The evolving landscape of pre-professional
pharmacy curricula.
Presented at the
annual meeting of the American Association of Colleges of Pharmacy,
Orlando, FL, 2012.
* denotes presenters.
Singh M and Moniri NH.
Reactive Oxygen Species are
required for
β2-adrenergic
receptor mediated
β-arrestin
signaling.
The
FASEB Journal.
Presented
at Experimental Biology (ASPET), Abstract #665.6, San Diego, CA, 2012.
Burns
RN and
Moniri NH.
Elucidation of the phosphorylation profiles of the long and short
isoforms of the omega-3 fatty acid receptor-1 (GPR120).
The
FASEB Journal.
Presented
at
Experimental Biology (ASPET),
Abstract #837.7, San Diego, CA, 2012.
Moniri NH.
Alternative teaching strategies in the classroom:
Development of critical thinking skills
using case studies.
Invited seminar presented at Mercer
University Georgia Baptist College of Nursing Faculty Retreat, January
5, 2012.
Moniri NH.
Development of critical thinking skills using case studies.
Invited seminar presented for the Mercer
University Council of Deans, September 9, 2011.
Moniri NH.
Oxidation of G protein-coupled receptors:
The role of ROS on
β2
adrenergic receptor signaling.
Presented at Mercer University College of
Pharmacy and Health Sciences Research Symposium, August 12, 2011.
Moniri NH,
Strom, JG, Ashworth LE, Barnett CW, Bartling JW, Klein CM.
A continuous improvement process for
integrated basic and clinical sciences courses in the PharmD curriculum.
Presented at the annual meeting of the
American Association of Colleges of Pharmacy, San Antonio, TX, 2011.
Burns RN and
Moniri NH.
Agonist-dependent oxidation of the
β2
adrenergic receptor: Selective cysteine sulfenic acid formation detected
by a modified biotin switch assay. The
FASEB Journal. Presented at Experimental
Biology (ASPET), Abstract #629.7, Washington, DC, 2011.
Moniri NH.
Regulation of the insulinotropic omega-3 fatty acid receptor GPR120 by
phosphorylation.
Presented at The Medical Center of Central
Georgia – Joint Research Conference, December 9, 2010.
Burns RN and
Moniri NH.
Omega-3
fatty acid mediated phosphorylation of the short and
long human GPR120 receptor isoforms.
The
FASEB Journal.
Presented
at Experimental
Biology (ASPET),
Abstract #585.6, Anaheim, CA, 2010.
Moniri NH.
Regulation of
β2-adrenergic
receptor signaling by reactive oxygen species.
Invited Seminar.
Presented at Georgia State University, Dept. of Biology, December 4,
2009.
Moniri NH
and Daaka Y.
β2-adrenergic
receptor mediated generation of reactive oxygen species is a component
required for signal transduction, desensitization, and homodimerization.
The
FASEB Journal.
Presented at Experimental Biology (ASPET),
Abstract #723.6,
San Diego, CA,
2008.
Burns RN, Hendy MA,
Moniri NH.
Cloning, expression, and initial functional
characterization of the human and rat free-fatty acid receptor GPR120.
American Society for Pharmacology and Experimental Therapeutics - SE
Region Abstracts.
Presented at ASPET-SEPS Region meeting,
Augusta, GA, 2007.
Booth RG and
Moniri NH.
Functionally selective ligands for the Histamine H1 GPCR.
Experimental Biology meeting
abstracts. Presented
at Experimental Biology (ASPET),
San Diego, CA, 2005.
Moniri NH and Booth
RG.
Functionally selective histamine
H1 receptor ligands stimulate tyrosine hydroxylase in bovine
adrenal chromaffin cells:
effects of PKC and PKA inhibition on H1-mediated
catecholamine synthesis.
Society for Neuroscience
Abstracts, Vol. 29, presented at Society for Neuroscience Meeting, New Orleans, LA,
2003.
Legere JA,
Moniri NH, Booth RG.
(±)-2-Dimethylamino-5-phenyl-1,2,3,4- tetrahydronaphthalene binds
to histamine H1 receptors and selectively modulates cAMP vs.
IP signaling pathways.
American Chemical Society Abstracts, Paper #590220, presented at
American Chemical Society Meeting,
New Orleans, LA,
2003.
Legere JA,
Moniri NH, Booth RG.
2-Dimethylamino-5-phenyl-1,2,3,4-tetrahydronaphthalenes: A new class of
ligands for histamine H1 and serotonin 5-HT2 type
receptors.
American Chemical Society
Abstracts, Paper #43231, presented at American Chemical Society
Meeting, New York City, NY, 2003.
Moniri NH,
Wyrick SD, Booth RG.
Novel ligands selectively activate histamine
H1 receptors coupled to IP vs. cAMP signaling pathways to
stimulate tyrosine hydroxylase.
Society for Neuroscience Abstracts, Vol. 28, Program No. 830.13,
presented at Society for Neuroscience Meeting, Orlando,
FL, 2002.
Ghoneim OM,
Covington DW,
Moniri
NH,
Booth RG.
Novel phenylaminotetralins stimulate IP
accumulation and dopamine synthesis in rat striatum.
Society for Neuroscience Abstracts, Vol. 28, Program No. 249.5,
presented at Society for Neuroscience Meeting,
Orlando,
FL,
2002.
Moniri
NH,
Wyrick,
SD, Booth RG.
New rigid diarylaminopropanes are histamine
H1 ligands that stimulate brain dopamine synthesis.
Society for Neuroscience Abstracts, Vol. 27, Program No. 479.20,
presented at Society for Neuroscience Meeting,
San Diego,
CA, 2001.
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