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Grant Awards Funded:
Drug disposition in Disease States – Diabetes. American Diabetes Association, 1987 – 1988, D’Souza, M.J., and Pollock, S.
Determination of Gastrointestinal transit times of different viscosity grades of chitosan derivatives in rats, Searle Pharmaceuticals, 1988 – 1989, Eshima, D., (PI at Emory University) and D’Souza M.J.
Stability of Fentanyl in infusion pumps, Northside Hospital, 1988, Pollock, S., (PI at Mercer University), & D’Souza M.J.
Cyclosporine Interactions in Animal Models of Hypertension and Diabetes.American Heart Association, 1988 – 1989, Pollock, S., (PI at Mercer University) and D’Souza M.J.
Research Equipment Grant,Eli Lilly & Company, 1988 – 1989, Gourley, D., (PI at Mercer University) Harris, W., Pollock, S., and D’Souza M.J.
Comparison of the pharmacodynamics and pharmacokinetic properties, of cyclosporine A and cyclosporine G in adjuvant - induced polyarthritis in rats”, Sandoz Pharmaceuticals, 1988 – 1989, Pollock, S., (PI at Mercer University), Matthews, H., and D’Souza M.J.
Acetaminophen and antipyrine disposition in normal volunteers and sickle cell anemic patients”, Mercer University, 1988 – 1989, Degree, D., (PI at Mercer University) and D’Souza M.J.
Buspirone/Cyclosporine interaction study in rats.Bristol Myers, 1989 – 1990, Jann, M., (PI at Mercer University) and D’Souza M.J.
Cyclosporine - Drug Interactions in Animal Models and Renal Transplant Patients. Mercer University, 1987 – 1988, D’Souza M.J., and Solomon H.
Drug-drug interactions, autoimmune diseases and bio-localization. Mercer University, 1988 – 1989, D’Souza M.J., and Pollock S.
Determination of methoprene and fenoxycarb levels in dog plasma samples Professional Laboratories and Research Services Inc., 1988 – 1989, D’Souza M.J.
Preparation and in-vitro release studies of microspheres containing antibodies to tumor necrosis factor-alpha,Dialysis Clinic Inc., 1990, D’Souza M.J., Oliver, J., and Oettinger, C.
Stability studies on microencapsulated antibody preparations, Dialysis Clinic Inc., 1990, D’Souza M.J., Oliver, J., and Oettinger, C.
Preparation of microspheres containing antibodies to interleukin 1-beta and interleukin-6, Dialysis Clinic Inc., 1991, D’Souza, M.J., Oliver, J., and Oettinger, C.
The Pharmacokinetics, Pharmacodynamics and Side Effects of Oxybutynin, Administered Intravesically", Emory University- Department of Urology, 1991 – 1992, Garretson, L., (PI at Emory University), Becker, B., Galloway, N., Irwin, P., and D’Souza M.J.
Effect of microspheres containing monoclonal antibodies to interleukin 8 and interluekin-1 receptor antagonist on cytokine release. Dialysis Clinic Inc., 1992, D’Souza M.J., Oliver J., and Oettinger, C.
Effect of Microencapsulated Cytokine Neutralizing Antibodies and Anti-CD3 Antibody on Acute rejection in a Mouse Heart Transplant Model, Dialysis Clinic Inc., 1993-1995, Pearson, T., (PI at Emory University), Oliver, J., Oettinger, C., Larsen, C., Gerber, D., Whelchel, J., and D’Souza M.J., (PI at Emory University)
Effect of monoclonal/polyclonal antibodies to cytokines in gram negative and gram positive animal models of septic shock, Dialysis Clinic Inc., 1992-1995, Oliver, J., (PI at Dialysis Clinic), D’Souza M.J., and Oettinger, C.
An Evaluation of Microspheres containing Monoclonal Antibodies to TNFalpha and IL-1B: Safety and Efficacy in Lethal gram Negative Peritonitis, Dialysis Clinic Inc., 1994-1997, McClure, H., (PI at Yerkes Primate Center), Oliver, J., Oettinger, C., Novembre, F., and D’Souza M.J.
Effect of Microspheres containing TNFalpha and IL-1B Neutralizing Antibodies on Cytokine Release In Vitro following OKT3, Equine antilymphocyte Globulin, Minnesota Antithymocyte Globulin and Rabbit Antithymocyte solution, Dialysis Clinic Inc., 1993-1995, D’Souza M.J., Oettinger, C., Oliver, J., Miller, H., and Johnson, K.
Effect of cytokine neutralizing antibodies on OKT-3 and ATS stimulated cytokine release in-vitro. Dialysis Clinic Inc., 1995-1996, D’Souza, M.J., Oliver, J., and Oettinger, C.
Novel sustained release microsphere formulations of AZT, Mercer University, 1996-1997, D’Souza M.J.
Microencapsulation of allotrax and its derivatives, Sangstat Medical Corporation, 1996-1997, D’Souza M.J.
Microencapsulation and in-vitro release studies of the immunosuppressant drug bc1nl Sangstat Medical Corporation, 1996-1997, D’Souza M.J.
Standardization and characterization of microencapsulated cytokine neutralizing antibodies, Dialysis Clinic Inc. 1996-1997, D’Souza M.J.
Standardization and characterization of microencapsulated anti-cytokine CNI-1493. Dialysis Clinic Inc. 1997-2000, D’Souza M.J.
Evaluation of microspheres containing cytokine neutralizing antibodies in septic shock – Part I . Dialysis Clinic Inc., 1997-2000, D’Souza M.J.
Preparation of microspheres of morpholino oligomers to TNF-alpha mRNA. Dialysis Clinic Inc., 1998-1999, D’Souza M.J.
Standardization of microencapsulated antagonists (i.e. CNI-1493) to cytokines using human whole blood, Dialysis Clinic Inc., 1998-1999, D’Souza M.J.
Evaluation of an anti-sense oligomer NF-kB, in the inhibition of cytokine production after endotoxin stimulation,Dialysis Clinic Inc., 1999-2001, D’Souza M.J.
Standardization of microencapsulated antagonist – anti-sense tumor necrosis factor oligomer, to cytokines.Dialysis Clinic Inc., 1999-2001, D’Souza M.J.
Preparation and testing of antisense and non-sense oligomers to NF-kB. 1999-2002, D’Souza M.J., Oettinger, C., and Weller, D., Dialysis Clinic Inc.,
Gene targeting: “Do increasing doses of microencapsulated anti-sense NF-kB progressively inhibit endotoxin induced cytokine synthesis in-vitroDialysis Clinic Inc., 2000-2004, D’Souza M.J., Oettinger, C., and Weller, D., Dialysis Clinic Inc.
Evaluation of the duration of efficacy of NF-kB antisense oligomers in inhibiting endotoxin induced cytokine release. 2000-2006, D’Souza M.J. Dialysis Clinic Inc.
Evaluation of microspheres prepared by the atomizer method with different drugs, oils, temperature and methodology. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Uptake kinetics of increasing doses of microspheres prepared by the new atomization process. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Effect of LPS on the uptake characteristics of microspheres. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.,
Effect of pre-treatment (4hrs) with microencapsulated antisense oligomers to NF-kB on the inhibition of cytokines in endothelial cells. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Preparation of microspheres of water insoluble drugs by a novel atomization method with different polymers, temperature and solvents. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Preparation and evaluation of microencapsulated alpha melanocyte stimulating hormone (alpha- MSH). D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Effects of NF-kB in the microspheres and solution form on endothelial cell permeability studies. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Analysis of cytokine levels in plasma. D’Souza M.J., & Oettinger, Dialysis Clinic Inc.
Evaluation of the uptake of microencapsulated gentamicin and anti-sense oligonucleotides to NF-kB in endothelial cells. D’Souza M.J., and Oettinger, Dialysis Clinic Inc.
Evaluation of the tear kinetics and surface reaction in the eye after topical administration of an ointment containing CGP 41251, a potential agent useful in the treatment of vascular diseases of the eye. D’Souza M.J. and Aukunuru Jithan. Novartis Pharmaceuticals
Evaluation of an oral encapsulated melanoma tumor vaccine. Martin D’Souza, Ravi Palaniappan, and Perisamy Selvaraj.
Formulation and in-vitro testing of oral vaccines for breast cancer. Martin D’Souza. This project evaluates the effect of variation of formulation parameters on the uptake of oral vaccines with breast cancer antigens
Evaluation of an oral nanoencapsulated influenza vaccine. Martin D’Souza and Sang-Moo Kang. This multiple PI one year collaborative grant between Mercer and Emory University, evaluates the development of an oral nanoencapsulated influenza vaccine
Oral Pneumonia Vaccines- Immune-potentiation of pneumococcal capsular polysaccharide vaccine using albumin and B-cyclodextrin encapsulation. Martin D’Souza, George Carlone and Gowrisankar Rajam and Nadine Rhouphael.
Agency: Dialysis Clinic Inc., Atlanta, GA
Comparison of TNF release and phagocytosis in macrophages, endothelial cells, neutrophils and dendritic cells. 5/2/08- 5/20/14. $ 75,000.00. This research project evaluates the uptake of nanospheres into different cell types and also examines cytokine release such as TNF-alpha.
Agency: Dialysis Clinic Inc., Atlanta, GA
The effect of endothelial uptake of microencapsulated anti-sense oligomers to NF-kB and catalase on cytokine production. 4/15/08- 8/29/14. $ 57,000.00. This project evaluates the effect of uptake of microspheres containing anti-sense oligomers to NF-kB and catalase into endothelial cells and the overall effect on cytokine production.
Agency: Dialysis Clinic Inc., Atlanta, GA
Effect of microencapsulated antisense oligomers to Nf-kB on cytokine production, Dialysis Clinic Inc. 4/15/08- 5/23/14. . This research projects evaluates the effect of microencapsulation of anti-sense oligomers to Nf-kB on cytokine production in macrophages and dendritic cells.
Agency: Dialysis Clinic Inc., Atlanta, GA
Effect of endothelial cell uptake or microencapsulated anti-sense oligomers to NF-kB and catalase on cytokine production in the ischemic kidney re-perfusion model. 5/25/08-4/30/14. . This study evaluates the effect of uptake of microencapsulated anti-sense oligomers to NF-kB into endothelial cells and the overall effect of cytokine production in the re-perfusion kidney model.
Agency: Abbott Laboratories
Formulation and stabilities studies of ABT and Bupernorphine. 1/6/08- 5/12/2013.
Agency: NIH 1R56AI087782
Novel nanotechnology based oral influenza vaccines. 4/01/2012- 06/31/2013 Mercer University, Sang-Moo Kang (PI) and Martin D’Souza (Co-PI). This multiple university one year collaborative grant between Mercer and Georgia State University, evaluates the development of an oral nanoencapsulated influenza vaccine
Agency: Center for Pediatric Nanomedicine at Emory University-Pilot Seed Award 6/01/2012-05/30/2014
Novel Oral Meningococcal Vaccine-Loaded Nanoparticles. Susu Zughaier (PI, Emory University), Nael McCarty (Co-PI, Emory University) & Martin D’Souza (Co-PI Mercer University). This multiple university one year pilot seed collaborative grant between Emory University and Mercer University, evaluates the development of an oral nanoencapsulated meningococcal vaccine
Agency: NIH R01AI105170.
Title: VLP Vaccine Technology 01/15/2013–01/14/2018 Sang-Moo Kang (PI, Georgia State University), Martin D’Souza (Co-PI, Mercer University); Mark Prausnitz (Co-PI, Georgia Tech); Martin Moore (Co-PI, Emory University) and Dr. York (Collaborator, CDC),
This is a collaborative 5-year grant was awarded to Dr. Sang-Moo Kang as the PI. I am the Co-PI along with Drs. Martin Moore (Emory University), Dr. Mark Prausnitz (Georgia Tech) and Dr. York (Collaborator, CDC). This project examines the VLP vaccine technology as applied to VLP Influenza and RSV vaccines delivered via the oral route (using nanoparticles) and transdermally.
Agency: NIH 1R41CA180773
Title: Ovarian cancer vaccine using novel nanoparticle formulations. 08/01/2014-07/30/2016. This multiple PI collaborative 2-year grant was awarded to Dr. Martin D’Souza (Mercer University) and Maurizio Chiriva-Internati (Texas Tech University, Lubbock, TX)
This project examines the effect or orally administered ovarian cancer nanoparticulate vaccines on the remission of existing ovarian cancers in murine models
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