GRANT AWARDS FUNDED:
AS PRINCIPAL
INVESTIGATOR
GRANT AWARDS FUNDED AS PRINCIPAL INVESTIGATOR
Title: Drug disposition in Disease States – Diabetes. American Diabetes Association, 1987 – 1988, D’Souza, M.J., and Pollock, S., $ 5,000.00
Title: Cyclosporine - Drug Interactions in Animal Models and Renal Transplant Patients. Mercer University, 1987 – 1988, D’Souza M.J., and Solomon H., $ 2,000.00
Title: Drug-drug interactions, autoimmune diseases and bio-localization. Mercer University, 1988 – 1989, D’Souza M.J., and Pollock S., $ 2,000.00
Title: Determination of methoprene and fenoxycarb levels in dog plasma samples Professional Laboratories and Research Services Inc., 1988 – 1989, D’Souza M.J., $ 2,815.00
Title: Preparation and in-vitro release studies of microspheres containing antibodies to tumor necrosis factor-alpha, Dialysis Clinic Inc., 1990, D’Souza M.J., Oliver, J., and Oettinger, C., $ 52,500.00
Title: Stability studies on microencapsulated antibody preparations, Dialysis Clinic Inc., 1990, D’Souza M.J., Oliver, J., and Oettinger, C., $ 62,400.00
Title: Preparation of microspheres containing antibodies to interleukin 1-beta and interleukin-6, Dialysis Clinic Inc., 1991, D’Souza, M.J., Oliver, J., and Oettinger, C., $ 34,500.00
Title: Effect of microspheres containing monoclonal antibodies to interleukin 8 and interluekin-1 receptor antagonist on cytokine release. Dialysis Clinic Inc., 1992, D’Souza M.J., Oliver J., and Oettinger, C., $ 13,700.00
Title: Effect of Microspheres containing TNFalpha and IL-1B Neutralizing Antibodies on Cytokine Release In Vitro following OKT3, Equine antilymphocyte Globulin, Minnesota Antithymocyte Globulin and Rabbit Antithymocyte solution, Dialysis Clinic Inc., 1993-1995, D’Souza M.J., Oettinger, C., Oliver, J., Miller, H., and Johnson, K., $ 5,592.00
Title: Effect of cytokine neutralizing antibodies on OKT-3 and ATS stimulated cytokine release in-vitro. Dialysis Clinic Inc., 1995-1996, D’Souza, M.J., Oliver, J., and Oettinger, C., $ 8,500.00
Title: Novel sustained release micsosphere formulations of AZT, Mercer University, 1996-1997, D’Souza M.J., $ 9000.00,
Title: Microencapsulation of allotrax and its derivatives, Sangstat Medical Corporation, 1996-1997, D’Souza M.J., $5,485.00
Title: Microencapsulation and in-vitro release studies of the immunosuppressant drug bc1nl Sangstat Medical Corporation, 1996-1997, D’Souza M.J., $ 2,358.75
Title: Standardization and characterization of microencapsulated cytokine neutralizing antibodies, Dialysis Clinic Inc. 1996-1997, D’Souza M.J., $ 31,617.60
Title: Standardization and characterization of microencapsulated anti-cytokine CNI-1493. Dialysis Clinic Inc. 1997-2000, D’Souza M.J., $ 22,800.00
Title: Evaluation of microspheres containing cytokine neutralizing antibodies in septic shock – Part I . Dialysis Clinic Inc., 1997-2000, D’Souza M.J., $ 14,759.00
Title: Preparation of microspheres of morpholino oligomers to TNF-alpha mRNA. Dialysis Clinic Inc., 1998-1999, D’Souza M.J., $ 2,040.00
Title: Standardization of microencapsulated antagonists (i.e. CNI-1493) to cytokines using human whole blood, Dialysis Clinic Inc., 1998-1999, D’Souza M.J., $ 15,066.00
Title: Evaluation of an anti-sense oligomer NF-kB, in the inhibition of cytokine production after endotoxin stimulation, Dialysis Clinic Inc., 1999-2001, D’Souza M.J., $ 5,971.60
Title: Standardization of microencapsulated antagonist – anti-sense tumor necrosis factor oligomer, to cytokines. Dialysis Clinic Inc., 1999-2001, D’Souza M.J., $ 7,353.60
Title: Preparation and testing of antisense and non-sense oligomers to NF-kB. 1999-2002, D’Souza M.J., Oettinger, C., and Weller, D., Dialysis Clinic Inc., 2000-2002 $13,764.00
Title: Gene targeting: “Do increasing doses of microencapsulated anti-sense NF-kB progressively inhibit endotoxin induced cytokine synthesis in-vitro Dialysis Clinic Inc., 2000-2004, D’Souza M.J., Oettinger, C., and Weller, D., Dialysis Clinic Inc., $ 11,062.02
Title: Evaluation of the duration of efficacy of NF-kB antisense oligomers in inhibiting endotoxin induced cytokine release. 2000-2006, D’Souza M.J. Dialysis Clinic Inc., $ 23,568.00
Title: Evaluation of microspheres prepared by the atomizer method with different drugs, oils, temperature and methodology. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 23,656.20
Title: Uptake kinetics of increasing doses of microspheres prepared by the new atomization process. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 7,549.20
Title: Effect of LPS on the uptake characteristics of microspheres. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 5,539.20
Title: Effect of pre-treatment (4hrs) with microencapsulated antisense oligomers to NF-kB on the inhibition of cytokines in endothelial cells. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 7,083.60
Title: Preparation of microspheres of water insoluble drugs by a novel atomization method with different polymers, temperature and solvents. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 13, 642.60
Title: Preparation and evaluation of microencapsulated alpha melanocyte stimulating hormone (alpha-
MSH). D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 9,900.00
Title: Effects of NF-kB in the microspheres and solution form on endothelial cell permeability studies. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 17,442.00
Title: Analysis of cytokine levels in plasma. D’Souza M.J., & Oettinger, Dialysis Clinic Inc., $ 18,571.20
Title: Evaluation of the uptake of microencapsulated gentamicin and anti-sense oligonucleotides to NF-kB in endothelial cells. D’Souza M.J., and Oettinger, Dialysis Clinic Inc., $ 19,962.00
Title: Evaluation of the tear kinetics and surface reaction in the eye after topical administration of an ointment containing CGP 41251, a potential agent useful in the treatment of vascular diseases of the eye. D’Souza M.J. and Aukunuru Jithan. Novartis Pharmaceuticals $ 4404.00
Title: Comparison of TNF inhibition and duration of action of morpholino antisense oligomers to NF-kB with phosphorothioate antisense oligomers. Dialysis Clinic Inc. $ 12,607.60
Title: Effect of microencapsulated blank oligomers to TNF on cytokines. Dialysis Clinic Inc. 8,999.00
Title: Preparation and evaluation of microencapsulated pyrrolidine dithiocarbamate- II, Continuation: Data and Statistical Analysis. Dialysis Clinic Inc. $ 1230.00
Title: Preparation and evaluation of microspheres of anti-sense oligomers to Nf-kB and CNI-1493- II, Continuation: Data and Statistical Analysis. Dialysis Clinical Inc, $ 1230.00
Title: Determination of differential absorption of impurities from a commercially available poloxamer. ExtRx Corporation. 2003-2005. 9,930.00
Title: Permeation of different charged drugs through epithelial cells as parameter for formulation development. Novartis Opthalmics. 2003-2008. $ 22.911.00
Title: Comparison of TNF release and phagocytosis in macrophages, endothelial cells, neutrophils and dendritic cells. Dialysis Clinic Inc., 2004-2010. $ 6981.60
Title: Effect of the gentamicin microspheres in the treatment of E.Coli induced septic shock rats. Dialysis Clinic Inc., 2004-2009. $ 12,448.80
Title: The effect of endothelial uptake of microencapsulated anti-sense oligomers to NF-kB and catalase on cytokine production, Dialysis Clinic Inc., 2004-2009, $ 35,570.00
Title: Evaluation of the effect of microencapsulated anti-cytokine drugs on arthritis. Dialysis Clinic Inc.2004-2009, $ 34,540.80
Title: Evaluation of the efficacy of Vancomycin microspheres, Dialysis Clinic Inc. 2005-2007, $ 23,445.60
Title: Determination of the toxicity of the microspheres to anti-sense oligonucleotides to NF-Kb, Dialysis Clinic Inc. 2006-2009, $ 29,946.00
Title: Effect of catalase formulations on the inhibition of E. Coli induced NF-kB p65 subunit expression (microspheres vs solution), Dialysis Clinic Inc. 2006-2009, $ 24,804.00
Title: Effect of microencapsulated antisense oligomers to Nf-kB on cytokine production, Dialysis Clinic Inc. 2006-2012, $ 39,434.40
Title: Analgesic formulation development studies using ELISA or RIA assay methods, Abbott Laboratories, 2006-2010, $ 48,697.00
Title: Effect of endothelial cell uptake or microencapsulated anti-sense oligomers to NF-kB and catalase on cytokine production in the ischemic re-perfusion model-II. Dialysis Clinic Inc., 2006-2008 $ 51,732.00
Title: Evaluation of ocular tetracaine formulations in rabbits, Encompass Development Corporation, 2006-2009, $ 12,960.00
Title: Evaluation of ocular atropine formulations in rabbits, Encompass Development Corporation, 2007-2009, $ 26,196.00
Title: Combination studies of gentamicin and NF-kB microspheres, Dialysis Clinic Inc. 2007-2015, $ 29,251.20
Title: Stability studies of NF-kB microsphere formulation, Dialysis Clinic Inc. 2007-2015, $ 28,756.20
GRANTS SUBMITTED/PENDING:
Title: Oral hepatitis B vaccine delivery system for prophylactic use.
Granting Agency: National Institute of Health- Grand Challenges in Global
Amount: $ 1,400,093.00
Title: Oral malaria, typhoid, tetanus, diphtheria and pertussis vaccine delivery systems for prophylactic use.
Granting Agency: Department of Defense (DOD
Amount: $ 1,950,000.00
GRANT AWARDS FUNDED AS CO-INVESTIGATOR
Title: Stability of Fentanyl in infusion pumps, Northside Hospital, 1988, Pollock, S., (PI at Mercer University), & D’Souza M.J., $ 3,000.00
Title: Cyclosporine Interactions in Animal Models of Hypertension and Diabetes. American Heart Association, 1988 – 1989, Pollock, S., (PI at Mercer University) and D’Souza M.J., $ 21,425.00
Title: Research Equipment Grant, Eli Lilly & Company, 1988 – 1989, Gourley, D., (PI at Mercer University) Harris, W., Pollock, S., and D’Souza M.J., $ 10,000.00
Title: Comparison of the pharmacodynamics and pharmacokinetic properties, of cyclosporine A and cyclosporine G in adjuvant - induced polyarthritis in rats”, Sandoz Pharmaceuticals, 1988 – 1989, Pollock, S., (PI at Mercer University), Matthews, H., and D’Souza M.J., $ 10,000.00
Title: "Acetaminophen and antipyrine disposition in normal volunteers and sickle cell anemic patients”, Mercer University, 1988 – 1989, Degree, D., (PI at Mercer University) and D’Souza M.J., $ 2,000.00
Title: Buspirone/Cyclosporine interaction study in rats. Bristol Myers, 1989 – 1990, Jann, M., (PI at Mercer University) and D’Souza M.J., $ 1,500.00
Title: Determination of Gastrointestinal transit times of different viscosity grades of chitosan derivatives in rats, Searle Pharmaceuticals, 1988 – 1989, Eshima, D., (PI at Emory University) and D’Souza M.J., $ 6,000.00
Title: "The Pharmacokinetics, Pharmacodynamics and Side Effects of Oxybutynin, Administered Intravesically", Emory University- Department of Urology, 1991 – 1992, Garretson, L., (PI at Emory University), Becker, B., Galloway, N., Irwin, P., and D’Souza M.J, $ 5,000.00
Title: Effect of Microencapsulated Cytokine Neutralizing Antibodies and Anti-CD3 Antibody on Acute rejection in a Mouse Heart Transplant Model, Dialysis Clinic Inc., 1993-1995, Pearson, T., (PI at Emory University), Oliver, J., Oettinger, C., Larsen, C., Gerber, D., Whelchel, J., and D’Souza M.J., (PI at Emory University), $ 10,000.00
Title: Effect of monoclonal/polyclonal antibodies to cytokines in gram negative and gram positive animal models of septic shock, Dialysis Clinic Inc., 1992-1995, Oliver, J., (PI at Dialysis Clinic), D’Souza M.J., and Oettinger, C., $ 181,000.00
Title: An Evaluation of Microspheres containing Monoclonal Antibodies to TNFalpha and IL-1B: Safety and Efficacy in Lethal gram Negative Peritonitis, Dialysis Clinic Inc., 1994-1997, McClure, H., (PI at Yerkes Primate Center), Oliver, J., Oettinger, C., Novembre, F., and D’Souza M.J., $ 231,025.00